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Bone Marrow Stimulants
Name | Dose (Adults) | Dose (Paediatric) | Precautions |
| Erythropoietin | 3000-15000 units- 3 times a week- SC | 50-100IU/kg- Thrice a week | Adjust the dose as per response. Hold if Hb >10 (as this can cause VTE/ stroke), Monitor BP, avoid in uncontrolled hypertension. W/F PRCA, Seizures Ensure adequate iron stores |
| Darbapoietin | 25-300mcg- SC- Once a week | Adjust the dose as per response. Hold if Hb >10 (as this can cause VTE/ stroke), Monitor BP, avoid in uncontrolled hypertension. W/F PRCA, Seizures Ensure adequate iron stores | |
| G-CSF | 300mcg- OD- SC | 5mcg/kg- OD- SC | Give till TLC>3500/cmm, W/F- Bone pains, diarrhea, fever |
| Peg-G-CSF | 6mg- SC- Stat | Given after completion of chemo, where there is anticipated neutropenia | |
| Eltrombopag | 50mg- OD- at 4 am | Adjust the dose to maintain platelet count just above 50,000/cmm. Monitor LFT, Decrease dose SOS Avoid with Iron, aluminium and magnesium salts. | |
| Romiplostin | 1microgram/Kg- SC- once a week. Increase the dose by 1microgram/Kg every week with target platelet count of 50,000/cmm |
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