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A user-friendly, frequently updated reference guide that aligns with international guidelines and protocols.
Immunosuppressants
Name | Dose (Adults) | Dose (Paediatric) | Precautions |
| Tacrolimus | 0.02mg/Kg- PO- BD. (Target Tacrolimus levels- 3-7ng/mL) | Avoid with Amphotericin, W/F Diarrhea, nephrotoxicity, hypertension, hyperglycemia, hypomagnesemia, abdominal pain, neurotoxicity Discontinue CSA 24 hrs prior to starting Tacrolimus | |
| Sirolimus | 5mg-OD | W/F Peripheral edema, hyperlipidaemia, decreased PL count, Progressive multifocal leukoencephalopathy, avoid with CSA/Tacro | |
| Ciclosporine | 150-300mg- BD-PO (2.5mg/kg- BD) | Avoid with Amphotericin B, W/F- Tremors, nephrotoxicity, Microangiopathy, hypertension, hirsutism, hypelipidemia, paraesthesia, TTP, Neurotoxicity with methyl prednisolone, monitor trough level (6am). Adjust dose accordingly. | |
| Mycophenolatemofetil | 500-1000mg BD 1hr prior or 2 hrs after meals | Avoid with penicillin group antibiotics and other immunosuppressants. Monitor BSL, Cholesterol, Mg, CBC, Ca, BP and K W/F Diarrhoea and vomiting Use double contraception and continue for 6 weeks after stopping. |
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