Myelodysplastic neoplasms, with defining genetic abnormalities
- Myelodysplastic neoplasm with low blasts and 5q deletion
- Myelodysplastic neoplasm with low blasts and SF3B1 mutation
- Myelodysplastic neoplasm with biallelic TP53 inactivation
Myelodysplastic neoplasms, morphologically defined
- Myelodysplastic neoplasm with low blasts
- Myelodysplastic neoplasm, hypoplastic
- Myelodysplastic neoplasm with increased blasts
Myelodysplastic neoplasms of childhood
- Childhood myelodysplastic neoplasm with low blasts
- Childhood myelodysplastic neoplasm with increased blasts

Myelodysplastic/myeloproliferative neoplasms

Chronic myelomonocytic leukaemia
Myelodysplastic/myeloproliferative neoplasm with neutrophilia
Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis
Myelodysplastic/myeloproliferative neoplasm, NOS

Acute myeloid leukaemia

Acute myeloid leukaemia with defining genetic abnormalities
- Acute promyelocytic leukaemia with PML::RARA fusion
- Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion
- Acute myeloid leukaemia with CBFB::MYH11 fusion
- Acute myeloid leukaemia with DEK::NUP214 fusion
- Acute myeloid leukaemia with RBM15::MRTFA fusion
- Acute myeloid leukaemia with BCR::ABL1 fusion
- Acute myeloid leukaemia with KMT2A rearrangement
- Acute myeloid leukaemia with MECOM rearrangement
- Acute myeloid leukaemia with NUP98 rearrangement
- Acute myeloid leukaemia with NPM1 mutation
- Acute myeloid leukaemia with CEBPA mutation
Acute myeloid leukaemia, myelodysplasia-related
Acute myeloid leukaemia, defined by differentiation
- Acute myeloid leukaemia with minimal differentiation
- Acute myeloid leukaemia without maturation
- Acute myeloid leukaemia with maturation
- Acute basophilic leukaemia
- Acute myelomonocytic leukaemia
- Acute monocytic leukaemia
- Acute erythroid leukaemia
- Acute megakaryoblastic leukaemia
Myeloid sarcoma

Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions

Myeloid neoplasm post cytotoxic therapy
Myeloid neoplasms associated with germline predisposition
Myeloid proliferations associated with Down syndrome

Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement

Myeloid/lymphoid neoplasm with PDGFRA rearrangement
Myeloid/lymphoid neoplasm with PDGFRB rearrangement
Myeloid/lymphoid neoplasm with FGFR1 rearrangement
Myeloid/lymphoid neoplasm with JAK2 rearrangement
Myeloid/lymphoid neoplasm with FLT3 rearrangement
Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion
Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes

Acute leukaemias of mixed or ambiguous lineage

Acute leukaemia of ambiguous lineage with defining genetic abnormalities
- Mixed-phenotype acute leukaemia with BCR::ABL1 fusion
- Mixed-phenotype acute leukaemia with KMT2A rearrangement
- Acute leukaemia of ambiguous lineage with other defined genetic alterations
Acute leukaemia of ambiguous lineage, immunophenotypically defined
- Mixed-phenotype acute leukaemia, B/myeloid
- Mixed-phenotype acute leukaemia, T/myeloid
- Mixed-phenotype acute leukaemia, rare types
Acute leukaemia of ambiguous lineage, NOS
Acute undifferentiated leukaemia

Histiocytic/Dendritic cell neoplasms

Plasmacytoid dendritic cell neoplasms
- Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm
- Blastic plasmacytoid dendritic cell neoplasm
Langerhans cell and other dendritic cell neoplasms
- Langerhans cell histiocytosis
- Langerhans cell sarcoma
- Indeterminate dendritic cell tumour
- Interdigitating dendritic cell sarcoma
Histiocyte/macrophage neoplasms
- Juvenile xanthogranuloma
- Erdheim-Chester disease
- Rosai-Dorfman Disease
- ALK-positive histiocytosis
- Histiocytic sarcoma

B-cell lymphoid proliferations and lymphomas

Tumour like lesions with B-cell predominance
- IgG4-related disease
- Unicentric Castleman disease
- Idiopathic multicentric Castleman disease
- KSHV/HHV8-associated multicentric Castleman disease
Precursor B-cell neoplasms
- B-lymphoblastic leukaemia/lymphoma
  - B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy
  - B-lymphoblastic leukaemia/lymphoma with hypodiploidy
  - B-lymphoblastic leukaemia/lymphoma with iAMP21
  - B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion
  - B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features
  - B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement
  - B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion
  - B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features
  - B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion
  - B lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion
  - B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion
  - B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations
  - B-lymphoblastic leukaemia/lymphoma, NOS
Mature B-cell neoplasms
- Pre-neoplastic and neoplastic small lymphocytic proliferations
  - Monoclonal B-cell lymphocytosis
- Chronic lymphocytic leukaemia/small lymphocytic lymphoma
- Splenic B-cell lymphomas and leukaemias
  - Hairy cell leukaemia
  - Splenic marginal zone lymphoma
  - Splenic diffuse red pulp small B-cell lymphoma
  - Splenic B-cell lymphoma/leukaemia with prominent nucleoli
- Lymphoplasmacytic lymphoma
- Marginal zone lymphoma
  - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
  - Primary cutaneous marginal zone lymphoma
  - Nodal marginal zone lymphoma
  - Paediatric nodal marginal zone lymphoma
- Follicular lymphoma
  - In situ follicular B-cell neoplasm
  - Follicular lymphoma
  - Paediatric-type follicular lymphoma
  - Duodenal-type follicular lymphoma
  - Cutaneous follicle centre lymphoma
  - Primary cutaneous follicle centre lymphoma
- Mantle cell lymphoma
  - In situ mantle cell neoplasm
  - Mantle cell lymphoma
  - Leukaemic non-nodal mantle cell lymphoma
- Transformations of indolent B-cell lymphomas
- Large B-cell lymphomas
  - Diffuse large B-cell lymphoma, NOS
  - T-cell/histiocyte-rich large B-cell lymphoma
  - Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2
  - rearrangements
  - ALK-positive large B-cell lymphoma
  - Large B-cell lymphoma with IRF4 rearrangement
  - High grade B-cell lymphoma with 11q aberrations
  - Lymphomatoid granulomatosis
  - EBV-positive diffuse large B-cell lymphoma
  - Diffuse large B-cell lymphoma associated with chronic inflammation
  - Fibrin-associated large B-cell lymphoma
  - Fluid overload-associated large B-cell lymphoma
  - Plasmablastic lymphoma
  - Primary large B-cell lymphoma of immune-privileged sites
  - Primary cutaneous diffuse large B-cell lymphoma, leg type
  - Intravascular large B-cell lymphoma
  - Primary mediastinal large B-cell lymphoma
  - Mediastinal grey zone lymphoma
- High-grade B-cell lymphoma, NOS
- Burkitt lymphoma
- KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
  - Primary effusion lymphoma

KSHV/HHV8-positive diffuse large B-cell lymphoma
KSHV/HHV8-positive germinotropic lymphoproliferative disorder

Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation

Hyperplasias arising in immune deficiency/dysregulation
- Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation
- EBV-positive mucocutaneous ulcer
Lymphomas arising in immune deficiency / dysregulation
Inborn error of immunity-associated lymphoid proliferations and lymphomas

Hodgkin lymphoma

Classic Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma

Plasma cell neoplasms and other diseases with paraproteins

Monoclonal gammopathies
- Cold agglutinin disease
- IgM monoclonal gammopathy of undetermined significance
- Non-IgM monoclonal gammopathy of undetermined significance
- Monoclonal gammopathy of renal significance
- Diseases with monoclonal immunoglobulin deposition
- Immunoglobulin-related (AL) amyloidosis
- Monoclonal immunoglobulin deposition disease
- Heavy chain diseases
  - Mu heavy chain disease
  - Gamma heavy chain disease
  - Alpha heavy chain disease
Plasma cell neoplasms
- Plasmacytoma
- Plasma cell myeloma / multiple myeloma
- Plasma cell neoplasms with associated paraneoplastic syndrome

T-cell and NK-cell lymphoid proliferations and lymphomas

Tumour-like lesions with T-cell predominance
- Kikuchi-Fujimoto disease
- Autoimmune lymphoproliferative syndrome
Indolent T-lymphoblastic proliferation
Precursor T-cell neoplasms
- T-lymphoblastic leukaemia / lymphoma
  - T-lymphoblastic leukaemia / lymphoma, NOS
  - Early T-precursor lymphoblastic leukaemia / lymphoma
Mature T-cell and NK-cell neoplasms
- T-prolymphocytic leukaemia
- T-large granular lymphocytic leukaemia
- NK-large granular lymphocytic leukaemia
- Adult T-cell leukaemia/lymphoma
- Sezary syndrome
- Aggressive NK-cell leukaemia
Primary cutaneous T-cell lymphoid proliferations and lymphomas
- Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder
- Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder
- Mycosis fungoides
- Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis
- Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma
- Subcutaneous panniculitis-like T-cell lymphoma
- Primary cutaneous gamma/delta T-cell lymphoma
- Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
- Primary cutaneous peripheral T-cell lymphoma, NOS
Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
- Indolent T-cell lymphoma of the gastrointestinal tract
- Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract
- Enteropathy-associated T-cell lymphoma
- Monomorphic epitheliotropic intestinal T-cell lymphoma
- Intestinal T-cell lymphoma, NOS
Hepatosplenic T-cell lymphoma
Anaplastic large cell lymphoma
- ALK-positive anaplastic large cell lymphoma
- ALK-negative anaplastic large cell lymphoma
- Breast implant-associated anaplastic large cell lymphoma
Nodal T-follicular helper (TFH) cell lymphoma
- Nodal TFH cell lymphoma, angioimmunoblastic-type
- Nodal TFH cell lymphoma, follicular-type
- Nodal TFH cell lymphoma, NOS
Other peripheral T-cell lymphomas
Peripheral T-cell lymphoma, NOS
EBV-positive NK-cell and T-cell lymphomas
- EBV-positive nodal T- and NK-cell lymphoma
- Extranodal NK/T-cell lymphoma
- EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood
  - Severe mosquito bite allergy
  - Hydroa vacciniforme lymphoproliferative disorder
- Systemic chronic active EBV disease
  - Systemic EBV-positive T-cell lymphoma of childhood

Stroma-derived neoplasms of lymphoid tissues

Mesenchymal dendritic cell neoplasms
- Follicular dendritic cell neoplasms
- Follicular dendritic cell sarcoma
- EBV-positive inflammatory follicular dendritic cell sarcoma
- Fibroblastic reticular cell tumour
Myofibroblastic tumours
- Myofibroblastic tumour
- Intranodal palisaded myofibroblastoma
Spleen-specific vascular-stromal tumours
- Splenic vascular-stromal tumours
- Littoral cell angioma
- Splenic hamartoma
- Sclerosing angiomatoid nodular transformation (SANT) of spleen

Genetic tumour syndromes

Fanconi anaemia
Bloom syndrome
Ataxia-telangiectasia syndrome
RASopathies

Howitreat.in

Wish to Reach Hematologists?

Advertise with Us!

Know More

Howitreat.in

Wish to Reach Hematologists?

Advertise with Us!

An Initiative of

Veenadhare Edutech Private Limited

1299, 2nd Floor, Shanta Nivas,

Beside Hotel Swan Inn, Off J.M.Road, Shivajinagar

Pune - 411005

Maharashtra – India

howitreat.in

CIN: U85190PN2022PTC210569

Email: admin@howitreat.in

Disclaimer: Information provided on this website is only for medical education purposes and not intended as medical advice. Although authors have made every effort to provide up-to-date information, the recommendations should not be considered standard of care. Responsibility for patient care resides with the doctors on the basis of their professional license, experience, and knowledge of the individual patient. For full prescribing information, including indications, contraindications, warnings, precautions, and adverse effects, please refer to the approved product label. Neither the authors nor publisher shall be liable or responsible for any loss or adverse effects allegedly arising from any information or suggestion on this website. This website is written for use of healthcare professionals only; hence person other than healthcare workers is advised to refrain from reading the content of this website.